Search results for " polygenic score"

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Genetic architecture of circulating lipid levels

2011

Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independen…

Netherlands Twin Register (NTR)MaleRiskQuantitative Trait LociPopulationBlood lipidsGenome-wide association study030204 cardiovascular system & hematologyBiologyQuantitative trait locusPolymorphism Single NucleotideArticle03 medical and health sciences0302 clinical medicineLipid Metabolism/geneticsGeneticSDG 3 - Good Health and Well-beingModelsGenetic variation/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_GeneticsHumansPolymorphismeducationSerum lipids; polygenic; genome-wide association; polygenic score; pathway analysisGenetics (clinical)030304 developmental biologyGenetic associationGenetics0303 health scienceseducation.field_of_studyModels GeneticLipids/bloodMetabolic Networks and Pathways/geneticsta3141Lipid metabolismSingle Nucleotideta3142Lipid MetabolismLipidsGenetic architecture3. Good healthPhenotype/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingFemalelipids (amino acids peptides and proteins)Quantitative Trait Loci/geneticsMetabolic Networks and PathwaysGenome-Wide Association StudyEuropean Journal of Human Genetics
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Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample…

2022

This work was supported by funding from the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). (...) CA was supported by the Spanish Ministry of Science and Innovation; Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), Fundación Familia Alonso and Fundación Alicia Koplowitz. MB was supported by the Ministry of Economy and Competitivity (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III – ERDF Funds from the European Commission, ‘A way of making Europ…

bipolar disorderAffective psychosisdiagnosisGENETIC-RELATIONSHIPSschizophrenia-spectrum disorderPsychiatry and Mental healthAffective psychosis bipolar disorder diagnosis genetics polygenic score psychosis psychotic depression schizophrenia-spectrum disorderLIABILITYpsychotic depressiongeneticspolygenic scorepsychosisGENOME-WIDE ASSOCIATIONApplied PsychologyPsychological Medicine
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